My worst was filling my 1200L tank. I dropped the level to about 50% during the clean. Set it to filling which takes about 30 minutes. Went outside for a minute to check the fishroom. An hour and a half later thought bugger I left the tank filling. Stepped inside the front door to squishy carpet. Around 1200L of water on the lounge floor - nice. It took 3 days to dry out. Needless to say I never did it again.
It caused a lot of damage. It stained the carpet, made and custom-wood furniture swell up including my speakers and smelled bad... Also the tank temp dropped to 20, not so good for discus. They all survived fine though.