Thanks so much for your reply. The patchiness I talked about is discolouration. My ammonia and nitrites are 0, the nitrates are lowering (now at 25) with the frequent changes. I added two new dalmation mollies to the tank about two months ago and plants around the same time. My original sick fish ended up lying on his side on the bottom of the tank in a bent position on Sunday so I thought he was near his end. I put him into a fry net (still in the main tank) so I could observe him and to stop the others bullying him. Yesterday, he actually righted himself and ate a little, and today he was swimming the right way up a little bit around the net - still a far way from being healthy but I thought it very strange for him to recover in any way at all! I have been doing frequent water changes, and I also added aquarium salt to the water, (did half rate because of the tetras) My other sick platy is getting more lethargic and wobbly, so I have moved them both to a quarantine tank today - I had fry in there so it was catch 22 as to whether I move the fry to my possibly infected main tank, but then I thought it was probably best to remove the two sick ones out in the hope that it is not the dreaded fish tb and thus prevent the rest becoming infected. I see one more of my platies though has developed black eyes and a rosy tetra is swimming tail down and not looking the best. The links you provided were very helpful, I have bookmarked the diagnostic link for future use and have ordered full length gloves today also. Thanks again for your help, I will see how things go.