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Columnaris and Furan 2 treatment advise

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Hi everyone! Here hoping to find some experiences using Furan 2. I am at day 3 dosing this medication as indicated by Hollywood Fish Farm, my big question is how were the fish reacting to it?. I have adults guppies and as soon as I did treatment 3 most of them started swimming erratically, not sure what to do now, if wait to see or try to do a water change to dilute somehow the medicine concentration. 

I'd appreciate your advise!

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